Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human IgA1 mAb
Ig alpha is the major immunoglobulin class in body secretions It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system In normal adult serum the approximate percentage composition of IgA with respect to is subclasses is IgA1 90% and IgA2 10% In secretory IgA the subclass proportions may approach 50 50 The clinical significance of the subclasses has yet to be determined
ABclonal Technology 647 Rabbit anti-Human Syk
This gene encodes a member of the family of non-receptor type Tyr protein kinases This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses including proliferation differentiation and phagocytosis It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology APC Rabbit anti-Human CD45RB
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 700 Rabbit anti-Human Ki67
Enables protein C-terminus binding activity Involved in regulation of chromosome segregation and regulation of mitotic nuclear division Located in chromosome nuclear body and nucleolus Colocalizes with condensed chromosome Implicated in Crohn s disease breast cancer human immunodeficiency virus infectious disease and pancreatic cancer Biomarker of several diseases including Barrett s esophagus autoimmune disease of musculoskeletal system (multiple) endocrine gland cancer (multiple) gastrointestinal system cancer (multiple) and interstitial cystitis
ABclonal Technology PE Rabbit anti-Human IL-5 mAb
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils The encoded cytokine plays a major role in the regulation of eosinophil formation maturation recruitment and survival The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases This cytokine functions by binding to its receptor which is a heterodimer whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2 GM-CSF) This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4) interleukin 13 (IL13) and CSF2 This gene IL4 and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31
ABclonal Technology 647 Rabbit anti-Human CD48
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins The encoded protein is found on the surface of lymphocytes and other immune cells dendritic cells and endothelial cells and participates in activation and differentiation pathways in these cells The encoded protein does not have a transmembrane domain however but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human CD46
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I which protects the host cell from damage by complement In addition the encoded protein can act as a receptor for the Edmonston strain of measles virus human herpesvirus-6 and type IV pili of pathogenic Neisseria Finally the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome Alternatively spliced transcript variants encoding different isoforms have been described
ABclonal Technology 488 Rabbit anti-Human CD300c
The CMRF35 antigen which was identified by reactivity with a monoclonal antibody is present on monocytes neutrophils and some T and B lymphocytes (Jackson et al 1992 [PubMed 1349532])
ABclonal Technology 594 Rabbit anti-Human CEACAM6
This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma This gene affects the sensitivity of tumor cells to adenovirus infection The protein encoded by this gene acts as a receptor for adherent-invasive E coli adhesion to the surface of ileal epithelial cells in patients with Crohn s disease This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19
ABclonal Technology 450 Rabbit anti-Human CD89
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils monocytes macrophages and eosinophils where it mediates immunologic responses to pathogens It interacts with IgA-opsonized targets and triggers several immunologic defense processes including phagocytosis antibody-dependent cell-mediated cytotoxicity and stimulation of the release of inflammatory mediators Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene
![REVMAB BIOSCIENCES USA INC Biotin Light Chain Rabbit anti-Human Monoclonal Antibody [RM129]](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00138964-32103102-BIOTINHUIGGLC-ELISA.PNG-250.jpg)
REVMAB BIOSCIENCES USA INC Biotin Light Chain Rabbit anti-Human Monoclonal Antibody [RM129]
Biotin Anti-Human Ig Light Chain Rabbit Monoclonal Antibody, Clone RM129 (50UG); ICC, IHC, FC, ELISA validated; Product info: www.revmab.com
ABclonal Technology 488 Rabbit anti-Human CD204
This gene encodes class A macrophage scavenger receptors which produce three isoforms (1 2 and 3) via alternative splicing These trimeric integral membrane glycoproteins are macrophage-specific and involved in various processes like atherosclerosis Alzheimer s disease and host defense Isoforms 1 and 2 mediate the endocytosis of modified low-density lipoproteins (LDLs) while isoform 3 despite having the necessary domain cannot internalize modified LDL due to altered intracellular processing and trapping within the endoplasmic reticulum Isoform 3 also inhibits the function of isoforms 1 and 2 when co-expressed suggesting a regulatory mechanism for scavenger receptor activity in macrophages
ABclonal Technology 594 Rabbit anti-Human CD72
Predicted to enable signaling receptor binding activity Predicted to be involved in cell adhesion Is integral component of plasma membrane
ABclonal Technology 488 Rabbit anti-Human CR2/CD21
This gene encodes a membrane protein which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) Alternatively spliced transcript variants encoding different isoforms have been found for this gene